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Unexplained fatigue or weakness: While some fatigue is expected during weight loss, severe or progressive weakness, especially if accompanied by other symptoms, should be evaluated to rule out electrolyte imbalances, thyroid dysfunction, or other medical conditions

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doi: 10.1002/dmrr.729 65 GaultVAKerrBDHarriottPFlattPR

Curcumin ameliorated diabetic neuropathy partially by inhibition of Nadph oxidase mediating oxidative stress in the spinal cord

Subcutaneous doses go into the fatty layer beneath the skin think belly, outer thigh, or the back of the upper arm at about a 45-degree angle